| May 10, 2026 | It’s been a little while, and a few things have happened. I’m now a scientist in the Wayment-Steele lab at UW-Madison! I’m having a lot of fun setting up some exciting stuff and look forward to showing some of it before long. There have been a few publications. Matt’s work on proton-sensing GPCRs is out in Cell, and both of Gabby’s MET kinase studies landed in eLife — the conserved regulatory motifs paper and its inhibitor-resistance mapping followup. A couple DMS tools have been published, too: Jingyou’s Rosace-AA in Bioinformatics Advances, Jerome’s Lilace in Genome Biology. There are also Pooja’s fragment screening against VatD in Structure, and a review of high-throughput mutational screens for membrane transporters with Silas and the Raman lab in Cell Chemical Biology. A preprint about a suite of codon foundation models using our DMS data in collaboration with the Goodarzi lab is up, as well as Donovan’s deep mutational scan of EccD3 in the mycobacterial ESX secretion system. |
| Jul 19, 2024 | Gabby’s followup preprint performing inhibitor screens against MET kinase libraries is now on biorXiv. Priyanka and I also published a review of an interesting recent preprint by Vincoff et al. which fine-tuned ESM-2 on fusion oncoproteins. Read it on PREreview: https://prereview.org/reviews/12658078 Finally, I just joined the organizing committee of the Atlas of Variant Effects seminar series. |
| May 24, 2024 | We had a few papers published recently: our paper on the drug transporter OCT1 was published in Molecular Cell, and our Rosace paper was just published in Genome Biology. Also, Matt’s preprint on a proton-sensing GPCR is up on bioRxiv, as well as Gabby’s preprint on MET kinase fusions and activating mutations. |
| Nov 11, 2023 | I was awarded an F32 through NIGMS for my proposal “Connecting structure and fitness landscapes to overcome antibiotic resistance.” |
| Aug 25, 2023 | I received a Mary Anne Koda-Kimble Seed Award for Innovation to support my efforts for massively combinatorial library generation for transformative pharmacogenomics, with an exciting acronym: SHRIMPLE. |
| Feb 26, 2023 | Samantha Martinez from the University of San Francisco spent the break in the lab working on a project with us, and gave a great presentation for the UCSF-USF internship program. Thanks for your hard work, Samantha! |
| Sep 26, 2022 | I am giving a seminar at the University of San Francisco: “Breaking things to see how they work: predicting antibiotic resistance with massively parallel assays.” Thanks to Professors Janet Yang (USF) and Bassem Al-Sady (UCSF) for the opportunity! |
| Sep 12, 2022 | Our review of the SMRs is online at JBC now: take a look! Still rocking in the structural era: a molecular overview of the Small Multidrug Resistance (SMR) transporter family |
| Aug 19, 2022 | Alexis started her PhD program in Biophysics at Johns Hopkins University - congrats! |
| Jul 27, 2022 | We just posted a preprint of our DMS library generation technique, DIMPLE. |
| Mar 20, 2022 | I’m attending the Ligand Recognition and Molecular Gating Gordon Research conference and seminar in Italy! |
| Feb 19, 2022 | I presented a poster at the 2022 Biophysical Society meeting. |
| Sep 01, 2021 | I started my postdoctoral appointment in the Fraser Lab at UCSF! |